Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

Author:

Berkers Celia R,Verdoes Martijn,Lichtman Eben,Fiebiger Edda,Kessler Benedikt M,Anderson Kenneth C,Ploegh Hidde L,Ovaa Huib,Galardy Paul J

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology,Biochemistry,Biotechnology

Reference25 articles.

1. Hideshima, T. et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 61, 3071–3076 (2001).

2. Rock, K.L. & Goldberg, A.L. Degradation of cell proteins and the generation of MHC class I–presented peptides. Annu. Rev. Immunol. 17, 739–797 (1999).

3. Glickman, M.H. & Ciechanover, A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol. Rev. 82, 373–428 (2002).

4. Kisselev, A.F. & Goldberg, A.L. Proteasome inhibitors: from research tools to drug candidates. Chem. Biol. 8, 739–758 (2001).

5. Adams, J. et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 59, 2615–2622 (1999).

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