Genome-wide association studies for complex traits: consensus, uncertainty and challenges-Reference-Cited by-同舟云学术

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Genome-wide association studies for complex traits: consensus, uncertainty and challenges

Published:2008-05 Issue:5 Volume:9 Page:356-369
ISSN:1471-0056
Container-title:Nature Reviews Genetics
language:en
Short-container-title:Nat Rev Genet

Author:

McCarthy Mark I.,Abecasis Gonçalo R.,Cardon Lon R.,Goldstein David B.,Little Julian,Ioannidis John P. A.,Hirschhorn Joel N.

Publisher

Springer Science and Business Media LLC

Subject

Genetics(clinical),Genetics,Molecular Biology

Link

http://www.nature.com/articles/nrg2344.pdf

Reference127 articles.

1. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661–678 (2007). In this study, high density, genome-wide association data on 17,000 individuals identified many novel complex-trait susceptibility loci and explored key methodological and technical issues relevant to the GWA approach.

2. Todd, J. A. et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nature Genet. 39, 857–864 (2007).

3. Hakonarson, H. et al. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature 448, 591–594 (2007).

4. Sladek, R. et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445, 881–885 (2007).

5. Zeggini, E. et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316, 1336–1341 (2007).

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