Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die-Reference-Cited by-同舟云学术

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Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die

Published:2016-12-09 Issue:2 Volume:24 Page:317-329
ISSN:1350-9047
Container-title:Cell Death & Differentiation
language:en
Short-container-title:Cell Death Differ

Author:

Hwang Jee-Yeon,Gertner Michael,Pontarelli Fabrizio,Court-Vazquez Brenda,Bennett Michael Vander Laan,Ofengeim Dimitry,Zukin Ruth Suzanne

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/cdd2016140.pdf

Reference58 articles.

1. Hay N, Sonenberg N . Upstream and downstream of mTOR. Genes Dev 2004; 18: 1926–1945.

2. Klann E, Dever TE . Biochemical mechanisms for translational regulation in synaptic plasticity. Nat Rev Neurosci 2004; 5: 931–942.

3. Laplante M, Sabatini DM . mTOR signaling in growth control and disease. Cell 2012; 149: 274–293.

4. Huang J, Manning BD . A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 2009; 37: 217–222.

5. Darnell JC, Klann E . The translation of translational control by FMRP: therapeutic targets for FXS. Nat Neurosci 2013; 16: 1530–1536.

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