PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer-Reference-Cited by-同舟云学术

PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer

Published:2017-02-21 Issue:1 Volume:7 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Milella Michele,Falcone Italia,Conciatori Fabiana,Matteoni Silvia,Sacconi Andrea,De Luca Teresa,Bazzichetto Chiara,Corbo Vincenzo,Simbolo Michele,Sperduti Isabella,Benfante Antonina,Del Curatolo Anais,Cesta Incani Ursula,Malusa Federico,Eramo Adriana,Sette Giovanni,Scarpa Aldo,Konopleva Marina,Andreeff Michael,McCubrey James Andrew,Blandino Giovanni,Todaro Matilde,Stassi Giorgio,De Maria Ruggero,Cognetti Francesco,Del Bufalo Donatella,Ciuffreda Ludovica

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep43013.pdf

Reference58 articles.

1. Carracedo, A. & Pandolfi, P. P. The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene 27, 5527–5541, doi: 10.1038/onc.2008.247 (2008).

2. Fruman, D. A. & Rommel, C. PI3K and cancer: lessons, challenges and opportunities. Nat Rev Drug Discov 13, 140–156, doi: 10.1038/nrd4204 (2014).

3. De Luca, A., Maiello, M. R., D’Alessio, A., Pergameno, M. & Normanno, N. The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches. Expert Opin Ther Targets 16 Suppl 2, S17–27, doi: 10.1517/14728222.2011.639361 (2012).

4. Ciuffreda, L. et al. Signaling Intermediates (MAPK and PI3K) as Therapeutic Targets in NSCLC. Curr Pharm Des 20, 3944–3957 (2014).

5. Steelman, L. S. et al. Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. Leukemia 22, 686–707, doi: 10.1038/leu.2008.26 (2008).

Cited by 46 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Chemical composition of essential and fixed oils of Tagetes erecta fruits (Iran) and their implications in inhibition of cancer signaling;Scientific Reports;2024-08-24

2. STING activation increases the efficiency of temozolomide in PTEN harbouring glioblastoma cells;Turkish Journal of Medical Sciences;2024-06-12

3. PDGF, NGF, and EGF as main contributors to tumorigenesis in high-risk retinoblastoma;Frontiers in Oncology;2023-10-30

4. Bufalin serves as a pharmaceutic that mitigates drug resistance;Drug Metabolism Reviews;2023-04-27

5. BRAF-mediated brain tumors in adults and children: A review and the Australian and New Zealand experience;Frontiers in Oncology;2023-04-14