Simulations of Antigenic Variability in Influenza A
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Published:2008-09-15
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Volume:
Page:
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ISSN:1756-0357
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Container-title:Nature Precedings
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language:en
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Short-container-title:Nat Prec
Author:
Fachada Nuno,Lopes Vitor,Rosa Agostinho
Abstract
AbstractComputational models of the immune system (IS) and pathogenic agents have several applications, such as theory testing and validation, or as a complement to first stages of drug trials. One possible application is the prediction of the lethality of new Influenza A strains, which are constantly created due to antigenic drift and shift. Here, we present several simulations of antigenic variability in Influenza A using an agent-based approach, where low level molecular antigen-antibody interactions are explicitly described. Antigenic drift and shift events are analyzed regarding the virulence of emergent strains against the IS. Results are discussed from a qualitative point of view taking into account recent and generally recognized immunology and influenza literature.
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health
Cited by
1 articles.
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1. Influenza Immune Model Based on Agent;Proceedings of the 2015 Chinese Intelligent Systems Conference;2015-12-12