Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer: a novel mechanism for enhancing specific antigen presentation
-
Published:2007-10-05
Issue:
Volume:
Page:
-
ISSN:1756-0357
-
Container-title:Nature Precedings
-
language:en
-
Short-container-title:Nat Prec
Author:
Quah Ben,Barlow Vaughan,McPhun Virginia,Matthaei Klaus,Hulett Mark,Parish Christopher
Abstract
AbstractThe B cell antigen receptor (BCR) efficiently facilitates the capture and processing of a specific antigen for presentation on MHC class II molecules to antigen specific CD4+ T cells (1). Despite this, the majority of B cells are only thought to play a limited role in CD4+ T cell activation since BCRs are clonotypically expressed. Here we show, however, that activated B cells can, both in vitro and in vivo, rapidly donate their BCR to bystander B cells, a process that is mediated by direct membrane transfer between adjacent B cells and is amplified by the interaction of the BCR with specific antigen. This results in a dramatic expansion in the number of antigen-binding B cells in vivo, with the transferred BCR endowing recipient B cells with the ability to present specific antigen to antigen-specific CD4+ T cells.
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献