Forging a signature of in vivo senescence
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
http://www.nature.com/articles/nrc3960.pdf
Reference180 articles.
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4. Bodnar, A. G. et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349–352 (1998). This landmark paper provides direct evidence that experimental restoration of catalytically active telomerase in cultured human cells bypasses replicative senescence without causing oncogenic transformation.
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