6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling

Published:2015-10-19 Issue:11 Volume:17 Page:1484-1496
ISSN:1465-7392
Container-title:Nature Cell Biology
language:en
Short-container-title:Nat Cell Biol

Author:

Lin Ruiting,Elf Shannon,Shan Changliang^ORCID,Kang Hee-Bum,Ji Quanjiang,Zhou Lu,Hitosugi Taro,Zhang Liang,Zhang Shuai,Seo Jae Ho,Xie Jianxin,Tucker Meghan,Gu Ting-Lei,Sudderth Jessica,Jiang Lei,Mitsche Matthew,DeBerardinis Ralph J.,Wu Shaoxiong,Li Yuancheng,Mao Hui,Chen Peng R.,Wang Dongsheng,Chen Georgia Zhuo,Hurwitz Selwyn J.,Lonial Sagar,Arellano Martha L.,Khoury Hanna J.,Khuri Fadlo R.,Lee Benjamin H.,Lei Qunying,Brat Daniel J.,Ye Keqiang,Boggon Titus J.,He Chuan,Kang Sumin,Fan Jun,Chen Jing

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology

Link

http://www.nature.com/articles/ncb3255.pdf

Reference51 articles.

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3. Kroemer, G. & Pouyssegur, J. Tumor cell metabolism: cancer’s Achilles’ heel. Cancer Cell 13, 472–482 (2008).

4. Christofk, H. R. et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452, 230–233 (2008).

5. Hitosugi, T. et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell 22, 585–600 (2012).

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