Shared genetic architectures of educational attainment in East Asian and European populations
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Published:2024-01-05
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ISSN:2397-3374
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Container-title:Nature Human Behaviour
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language:en
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Short-container-title:Nat Hum Behav
Author:
Chen Tzu-TingORCID, Kim JaeyoungORCID, Lam MaxORCID, Chuang Yi-Fang, Chiu Yen-Ling, Lin Shu-Chin, Jung Sang-HyukORCID, Kim Beomsu, Kim SoyeonORCID, Cho ChamleeORCID, Shim InjeongORCID, Park SanghyeonORCID, Ahn YeeunORCID, Okbay AysuORCID, Jang Hyemin, Kim Hee Jin, Seo Sang Won, Park Woong-Yang, Ge Tian, Huang HailiangORCID, Feng Yen-Chen AnneORCID, Lin Yen-FengORCID, Myung WoojaeORCID, Chen Chia-YenORCID, Won Hong-HeeORCID
Abstract
AbstractEducational attainment (EduYears), a heritable trait often used as a proxy for cognitive ability, is associated with various health and social outcomes. Previous genome-wide association studies (GWASs) on EduYears have been focused on samples of European (EUR) genetic ancestries. Here we present the first large-scale GWAS of EduYears in people of East Asian (EAS) ancestry (n = 176,400) and conduct a cross-ancestry meta-analysis with EduYears GWAS in people of EUR ancestry (n = 766,345). EduYears showed a high genetic correlation and power-adjusted transferability ratio between EAS and EUR. We also found similar functional enrichment, gene expression enrichment and cross-trait genetic correlations between two populations. Cross-ancestry fine-mapping identified refined credible sets with a higher posterior inclusion probability than single population fine-mapping. Polygenic prediction analysis in four independent EAS and EUR cohorts demonstrated transferability between populations. Our study supports the need for further research on diverse ancestries to increase our understanding of the genetic basis of educational attainment.
Funder
National Research Foundation of Korea Korea Health Industry Development Institute Ministry of Science and Technology, Taiwan National Health Research Institutes
Publisher
Springer Science and Business Media LLC
Subject
Behavioral Neuroscience,Experimental and Cognitive Psychology,Social Psychology
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