Biophysical studies suggest a new structural arrangement of crotoxin and provide insights into its toxic mechanism-Reference-Cited by-同舟云学术

Biophysical studies suggest a new structural arrangement of crotoxin and provide insights into its toxic mechanism

Published:2017-03-03 Issue:1 Volume:7 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Fernandes Carlos A. H.,Pazin Wallance M.,Dreyer Thiago R.,Bicev Renata N.,Cavalcante Walter L. G.,Fortes-Dias Consuelo L.,Ito Amando S.,Oliveira Cristiano L. P.,Fernandez Roberto Morato,Fontes Marcos R. M.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep43885.pdf

Reference74 articles.

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2. Chang, C. C. & Lee, J. D. Crotoxin, the neurotoxin of South American rattlesnake venom, is a presynaptic toxin acting like beta-bungarotoxin. Naunyn Schmiedebergs Arch Pharmacol 296, 159–168 (1977).

3. Delot, E. & Bon, C. Model for the interaction of crotoxin, a phospholipase A2 neurotoxin, with presynaptic membranes. Biochemistry 32, 10708–10713 (1993).

4. Hendon, R. A. & Fraenkel-Conrat, H. Biological roles of the two components of crotoxin. Proc Natl Acad Sci USA 68, 1560–1563 (1971).

5. Faure, G., Xu, H. & Saul, F. A. Crystal structure of crotoxin reveals key residues involved in the stability and toxicity of this potent heterodimeric beta-neurotoxin. J Mol Biol 412, 176–191 (2011).

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