Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays-Reference-Cited by-同舟云学术

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Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays

Published:2015-11-16 Issue:1 Volume:5 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Shen Mingyun,Tian Sheng,Pan Peichen,Sun Huiyong,Li Dan,Li Youyong,Zhou Hefeng,Li Chuwen,Lee Simon Ming-Yuen,Hou Tingjun

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep16749.pdf

Reference63 articles.

1. Nakagawa, O. et al. ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 392, 189–193 (1996).

2. Ishizaki, T. et al. The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J. 15, 1885 (1996).

3. Matsui, T. et al. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J. 15, 2208 (1996).

4. Bishop, A. L. & Hall, A. Rho GTPases and their effector proteins. Biochem. J. 348, 241 (2000).

5. Pan, P. C. et al. Advances in the development of Rho-associated protein kinase (ROCK) inhibitors. Drug Discov. Today 18, 1323–1333 (2013).

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