A jumbo phage that forms a nucleus-like structure evades CRISPR–Cas DNA targeting but is vulnerable to type III RNA-based immunity-Reference-Cited by-同舟云学术

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A jumbo phage that forms a nucleus-like structure evades CRISPR–Cas DNA targeting but is vulnerable to type III RNA-based immunity

Published:2019-12-09 Issue:1 Volume:5 Page:48-55
ISSN:2058-5276
Container-title:Nature Microbiology
language:en
Short-container-title:Nat Microbiol

Author:

Malone Lucia M.,Warring Suzanne L.,Jackson Simon A.,Warnecke Carolin,Gardner Paul P.,Gumy Laura F.,Fineran Peter C.^ORCID

Funder

Marsden Fund from the Royal Society of New Zealand University of Otago Research Grant

University of Otago Doctoral Scholarship

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Microbiology (medical),Genetics,Applied Microbiology and Biotechnology,Immunology,Microbiology

Link

http://www.nature.com/articles/s41564-019-0612-5.pdf

Reference55 articles.

1. Hille, F. et al. The biology of CRISPR-Cas: backward and forward. Cell 172, 1239–1259 (2018).

2. Bryson, A. L. et al. Covalent modification of bacteriophage T4 DNA inhibits CRISPR-Cas9. mBio 6, e00648 (2015).

3. Vlot, M. et al. Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR–Cas effector complexes. Nucleic Acids Res. 46, 873–885 (2018).

4. Pawluk, A., Davidson, A. R. & Maxwell, K. L. Anti-CRISPR: discovery, mechanism and function. Nat. Rev. Microbiol. 16, 12–17 (2018).

5. Bondy-Denomy, J., Pawluk, A., Maxwell, K. L. & Davidson, A. R. Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system. Nature 493, 429–432 (2013).

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