HIV vaccine candidate plus microbicide decreases SIV infection risk by more than 90%
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Microbiology (medical),Genetics,Applied Microbiology and Biotechnology,Immunology,Microbiology
Link
https://www.nature.com/articles/s41564-023-01367-1.pdf
Reference5 articles.
1. Vaccari, M. et al. Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition. Nat. Med. 22, 762–770 (2016). This study reports the relevance of the macaque model of SIVmac251 infection to humans that recapitulated the protection of RV144 and predicted the futility in HVTN-702.
2. Vaccari, M. et al. HIV vaccine candidate activation of hypoxia and the inflammasome in CD14(+) monocytes is associated with a decreased risk of SIVmac251 acquisition. Nat. Med. 24, 847–856 (2018). This paper describes an important role of monocytes and low expression of CCR5 on vaccine-induced CD14+ T cells.
3. Rerks-Ngarm, S. et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N. Engl. J. Med. 361, 2209–2220 (2009). This paper reports the efficacy of the HIV vaccine trial RV144, a human study demonstrating some degree of efficacy.
4. Silva de Castro, I. et al. Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates. iScience 24, 102047 (2021). This study demonstrates that engineering of SIV envelope immunogens by V1 deletion improves vaccine efficacy by changing the conformation of V2.
5. Bissa, M. et al. HIV vaccine candidate efficacy in female macaques mediated by cAMP-dependent efferocytosis and V2-specific ADCC. Nat. Commun. 14, 575 (2023). This paper shows the importance of engagement of the CCL2/CCR2 axis and pro-resolution efferocytes to the efficacy of our HIV vaccine candidate.
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