Rebound virus in the cerebrospinal fluid reveals a possible HIV-1 reservoir
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Microbiology (medical),Genetics,Applied Microbiology and Biotechnology,Immunology,Microbiology
Link
https://www.nature.com/articles/s41564-022-01309-3.pdf
Reference4 articles.
1. Sengupta, S. & Siliciano, R. F. Targeting the latent reservoir for HIV-1. Immunity 48, 872–895 (2018). A review article that presents the nature of the HIV-1 latent reservoir and its role as a barrier to a cure.
2. Bednar, M. M. et al. Diversity and tropism of HIV-1 rebound virus populations in plasma level after treatment discontinuation. J. Infect. Dis. 214, 403–407 (2016). This paper reports that rebound virus in the blood after therapy discontinuation is diverse and adapted to replication in CD4+ T cells.
3. Joseph, S. B. & Swanstrom, R. The evolution of HIV-1 entry phenotypes as a guide to changing target cells. J. Leukoc. Biol. 103, 421–431 (2018). A review article that presents the characteristics of the HIV-1 envelope protein, how it influences cellular tropism and how it can evolve over the course of infection.
4. Zhou, S. et al. Unique molecular identifiers and multiplexing amplicons maximize the utility of deep sequencing to critically assess population diversity in RNA viruses. ACS Infect. Dis. 8, 2505–2514 (2022). This paper reports the importance of using unique molecular identifiers in next generation sequencing to overcome limitations such as PCR and sequencing errors and PCR resampling.
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