Uncontrolled transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of Cryptococcus neoformans-Reference-Cited by-同舟云学术

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Uncontrolled transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of Cryptococcus neoformans

Published:2022-08-02 Issue:8 Volume:7 Page:1239-1251
ISSN:2058-5276
Container-title:Nature Microbiology
language:en
Short-container-title:Nat Microbiol

Author:

Priest Shelby J.^ORCID,Yadav Vikas^ORCID,Roth Cullen,Dahlmann Tim A.,Kück Ulrich,Magwene Paul M.,Heitman Joseph

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

Deutsche Forschungsgemeinschaft

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Microbiology (medical),Genetics,Applied Microbiology and Biotechnology,Immunology,Microbiology

Link

https://www.nature.com/articles/s41564-022-01183-z.pdf

Reference75 articles.

1. Barrick, J. et al. Genome evolution and adaptation in a long-term experiment with Escherichia coli. Nature 461, 1243–1247 (2009).

2. Harfe, B. D. & Jinks-Robertson, S. Mismatch repair proteins and mitotic genome stability. Mutat. Res. 451, 151–167 (2000).

3. Billmyre, R. B., Croll, D. & Li, W. Highly recombinant VGII Cryptococcus gattii population develops clonal outbreak clusters through both sexual macroevolution and asexual microevolution. mBio 5, e01494–14 (2014).

4. Billmyre, R. B., Clancey, S. A. & Heitman, J. Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii. eLife 6, e28802 (2017).

5. Healey, K. R. et al. Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. Nat. Commun. 7, 11128 (2016).

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