Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Pathology and Forensic Medicine
Link
http://www.nature.com/articles/s41374-018-0091-y.pdf
Reference34 articles.
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2. Levy D, Garrison RJ, Savage DD, et al. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;322:1561–6.
3. Miele L, Giorgio V, Alberelli MA, et al. Impact of gut microbiota on obesity, diabetes, and cardiovascular disease risk. Curr Cardiol Rep. 2015;17:120.
4. Karbach SH, Schönfelder T, Brandão I, et al. Gut microbiota promote angiotensin II-induced arterial hypertension and vascular dysfunction. J Am Heart Assoc. 2016;5:e003698.
5. Organ CL, Otsuka H, Bhushan S, et al. Choline diet and its gut microbe-derived metabolite, trimethylamine N-oxide, exacerbate pressure overload-induced heart failure. Circ Heart Fail. 2016;9:e002314.
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