HIV-1 CCR5 gene therapy will fail unless it is combined with a suicide gene
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep18088.pdf
Reference24 articles.
1. Tebas, P. et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. New Engl J Med 370, 901–910 (2014).
2. Okoye, A. A. & Picker, L. J. CD4+ T-cell depletion in HIV infection: mechanisms of immunological failure. Immunol Rev 254, 54–64 (2013).
3. Sasson, S. C. & Kelleher, A. D. Site-specific host gene modification by zinc finger nucleases: pointing the way to drug free control of HIV-1? Clin Transl Immunology 3, e19 (2014).
4. Allers, K. et al. Evidence for the cure of hiv infection by ccr5δ32/δ32 stem cell transplantation. Blood 117, 2791–2799 (2011).
5. von Laer, D., Hasselmann, S. & Hasselmann, K. Impact of gene-modified T cells on HIV infection dynamics. J Theor Biol 238, 60–77 (2006).
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