PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3-Reference-Cited by-同舟云学术

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PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3

Published:2004-04-25 Issue:5 Volume:10 Page:530-534
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Koo Seung-Hoi,Satoh Hiroaki,Herzig Stephan,Lee Chih-Hao,Hedrick Susan,Kulkarni Rohit,Evans Ronald M,Olefsky Jerrold,Montminy Marc

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm1044.pdf

Reference28 articles.

1. Saltiel, A. & Kahn, C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799–806 (2001).

2. Hribal, M., Oriente, F. & Accili, D. Mouse models of insulin resistance. Am. J. Physiol. Endocrinol. Metab. 282, E977–E981 (2002).

3. Yoon, J. et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413, 131–138 (2001).

4. Herzig, S. et al. CREB regulates hepatic gluconeogenesis via the co-activator PGC-1. Nature 413, 179–183 (2001).

5. Rhee, J. et al. Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): requirement for hepatocyte nuclear factor 4α in gluconeogenesis. Proc. Natl. Acad. Sci. USA 100, 4012–4017 (2003).

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