The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling-Reference-Cited by-同舟云学术

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The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling

Published:2009-06-28 Issue:7 Volume:16 Page:691-697
ISSN:1545-9993
Container-title:Nature Structural & Molecular Biology
language:en
Short-container-title:Nat Struct Mol Biol

Author:

Bosanac Ivan,Maun Henry R,Scales Suzie J,Wen Xiaohui,Lingel Andreas,Bazan J Fernando,de Sauvage Frederic J,Hymowitz Sarah G,Lazarus Robert A

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Structural Biology

Link

http://www.nature.com/articles/nsmb.1632.pdf

Reference62 articles.

1. Ingham, P.W. & McMahon, A.P. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15, 3059–3087 (2001).

2. Jiang, J. & Hui, C.C. Hedgehog signaling in development and cancer. Dev. Cell 15, 801–812 (2008).

3. Beachy, P.A., Karhadkar, S.S. & Berman, D.M. Tissue repair and stem cell renewal in carcinogenesis. Nature 432, 324–331 (2004).

4. Scales, S.J. & de Sauvage, F.J. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol. Sci. 30, 303–312 (2009).

5. Lee, J.J. et al. Autoproteolysis in hedgehog protein biogenesis. Science 266, 1528–1537 (1994).

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