Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
http://www.nature.com/articles/nm.4266.pdf
Reference59 articles.
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2. Gallo, E.M. et al. Angiotensin-II-dependent TGF-β signaling contributes to Loeys–Dietz syndrome vascular pathogenesis. J. Clin. Invest. 124, 448–460 (2014).
3. Renard, M. et al. Novel MYH11 and ACTA2 mutations reveal a role for enhanced TGF-β signaling in FTAAD. Int. J. Cardiol. 165, 314–321 (2013).
4. Gillis, E., Van Laer, L. & Loeys, B.L. Genetics of thoracic aortic aneurysm: at the crossroad of transforming-growth-factor-β signaling and vascular smooth muscle cell contractility. Circ. Res. 113, 327–340 (2013).
5. Habashi, J.P. et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 312, 117–121 (2006).
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