Concurrent inhibition of CDK2 adds to the anti-tumour activity of CDK4/6 inhibition in GIST-Reference-Cited by-同舟云学术

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Concurrent inhibition of CDK2 adds to the anti-tumour activity of CDK4/6 inhibition in GIST

Published:2022-09-29 Issue:11 Volume:127 Page:2072-2085
ISSN:0007-0920
Container-title:British Journal of Cancer
language:en
Short-container-title:Br J Cancer

Author:

Schaefer Inga-Marie^ORCID,Hemming Matthew L.^ORCID,Lundberg Meijun Z.,Serrata Matthew P.,Goldaracena Isabel,Liu Ninning,Yin Peng,Paulo Joao A.^ORCID,Gygi Steven P.,George Suzanne,Morgan Jeffrey A.,Bertagnolli Monica M.,Sicinska Ewa T.,Chu Chen,Zheng Shanshan,Mariño-Enríquez Adrian^ORCID,Hornick Jason L.^ORCID,Raut Chandrajit P.,Ou Wen-Bin^ORCID,Demetri George D.,Saka Sinem K.^ORCID,Fletcher Jonathan A.

Funder

U.S. Department of Health & Human Services | National Institutes of Health

SARC (Sarcoma Alliance for Research through Collaboration) Young Investigator Award

United States Department of Defense | United States Navy | Office of Naval Research

Wyss Institute Validation Project Program

U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences

Pfizer and Lilly through the Alliance for Clinical Trials in Oncology

European Molecular Biology Laboratory (EMBL) core funding

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Link

https://www.nature.com/articles/s41416-022-01990-5.pdf

Reference56 articles.

1. Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998;279:577–80.

2. Heinrich MC, Corless CL, Duensing A, McGreevey L, Chen CJ, Joseph N, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science. 2003;299:708–10.

3. Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D, et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med. 2001;344:1052–6.

4. Heinrich MC, Rankin C, Blanke CD, Demetri GD, Borden EC, Ryan CW, et al. Correlation of long-term results of imatinib in advanced gastrointestinal stromal tumors with next-generation sequencing results: analysis of phase 3 SWOG intergroup trial S0033. JAMA Oncol. 2017;3:944–52.

5. Liegl B, Kepten I, Le C, Zhu M, Demetri GD, Heinrich MC, et al. Heterogeneity of kinase inhibitor resistance mechanisms in GIST. J Pathol. 2008;216:64–74.

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