Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival
Author:
Funder
Kræftens Bekæmpelse
Det Frie Forskningsråd
Novo Nordisk Fonden
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology
Link
https://www.nature.com/articles/s41416-022-01911-6.pdf
Reference57 articles.
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2. Lee S, Axelsen TV, Andersen AP, Vahl P, Pedersen SF, Boedtkjer E. Disrupting Na+,HCO3–-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development. Oncogene. 2016;35:2112–22.
3. Lee S, Axelsen TV, Jessen N, Pedersen SF, Vahl P, Boedtkjer E. Na+,HCO3–-cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice. Oncogene. 2018;37:5569–84.
4. Voss NCS, Dreyer T, Henningsen MB, Vahl P, Honoré B, Boedtkjer E. Targeting the acidic tumor microenvironment: unexpected pro-neoplastic effects of oral NaHCO3 therapy in murine breast tissue. Cancers. 2020;12:891.
5. Boedtkjer E, Pedersen SF. The acidic tumor microenvironment as a driver of cancer. Annu Rev Physiol. 2020;82:103–26.
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