A phase 1/2 trial of ibrutinib in combination with pembrolizumab in patients with mismatch repair proficient metastatic colorectal cancer-Reference-Cited by-同舟云学术

A phase 1/2 trial of ibrutinib in combination with pembrolizumab in patients with mismatch repair proficient metastatic colorectal cancer

Published:2021-04-07 Issue:11 Volume:124 Page:1803-1808
ISSN:0007-0920
Container-title:British Journal of Cancer
language:en
Short-container-title:Br J Cancer

Author:

Kim Dae Won,Tan Elaine,Zhou Jun-Min,Schell Michael J.,Martinez Maria,Yu James,Carballido Estrella,Mehta Rutika,Strosberg Jonathan,Imanirad Iman,Kim Richard D.

Funder

Janssen Pharmaceuticals

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Link

http://www.nature.com/articles/s41416-021-01368-z.pdf

Reference20 articles.

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3. Van Cutsem, E., Kohne, C. H., Hitre, E., Zaluski, J., Chang Chien, C. R., Makhson, A. et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N. Engl. J. Med. 360, 1408–1417 (2009).

4. Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D. et al. PD-1 blockade in tumors with mismatch-repair deficiency. N. Engl. J. Med. 372, 2509–2520 (2015).

5. Andre, T., Shiu, K., Kim, T., Jensen, B. V., Jensen, L. H., Punt, C. J. A. et al. Pembrolizumab versus chemotherapy for microsatellite instability-high/mismatch repair deficient metastatic colorectal cancer: The phase 3 KEYNOTE-177 Study. J. Clin. Oncol. https://doi.org/10.1200/JCO.2020.38.18_suppl.LBA4 (2020).

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