Low probability of disease cure in advanced ovarian carcinomas before the PARP inhibitor era
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Published:2022-03-31
Issue:1
Volume:127
Page:79-83
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ISSN:0007-0920
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Container-title:British Journal of Cancer
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language:en
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Short-container-title:Br J Cancer
Author:
You BenoitORCID, Van Wagensveld Lilian, Tod Michel, Sonke Gabe S., Horlings Hugo M.ORCID, Kruitwagen R. F. P. M., Du Bois Andreas, Selle Frédéric, Perren Timothy, Pfisterer Jacobus, Joly Florence, Cook Adrian, Kaminsky Marie Christine, Wollschlaeger Kerstin, Lortholary Alain, Tome Oliver, Leary Alexandra, Freyer Gilles, Van Der Aa Maaike, Colomban OlivierORCID
Abstract
Abstract
Background
In ovarian carcinomas, the likelihood of disease cure following first-line medical-surgical treatment has been poorly addressed. The objective was to: (a) assess the likelihood of long-term disease-free (LDF) > 5 years; and (b) evaluate the impact of the tumour primary chemosensitivity (assessed with the modelled CA-125 KELIM) with respect to disease stage, and completeness of debulking surgery.
Methods
Three Phase III trial datasets (AGO-OVAR 9; AGO-OVAR 7; ICON-7) were retrospectively investigated in an “adjuvant dataset”, whilst the Netherlands Cancer Registry was used in a “neoadjuvant dataset”. The prognostic values of KELIM, disease stage and surgery outcomes regarding the likelihood of LDF were assessed using univariate/multivariate analyses.
Results
Of 2029 patients in the “adjuvant dataset”, 82 (4.0%) experienced LDF (Stage I–II: 25.9%; III: 2.1%; IV: 0.5%). Multivariate analyses identified disease stage and KELIM (OR = 4.24) as independent prognostic factors. Among the 1452 patients from the “neoadjuvant dataset”, 36 (2.4%) had LDF (Stage II–III: 3.3%; IV: 1.3%). Using multivariate tests, high-risk diseases (OR = 0.18) and KELIM (OR = 2.96) were significant.
Conclusion
The probability of LDF > 5 years after first-line treatment in 3486 patients (<4%) was lower than thought. These data could represent a reference for future studies meant to assess progress related to PARP inhibitors.
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology
Reference19 articles.
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