How a faecal immunochemical test screening programme changes annual colorectal cancer incidence rates: an Italian intention-to-screen study
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Published:2022-04-20
Issue:3
Volume:127
Page:541-548
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ISSN:0007-0920
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Container-title:British Journal of Cancer
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language:en
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Short-container-title:Br J Cancer
Author:
Bucchi LauroORCID, Mancini SilviaORCID, Baldacchini Flavia, Ravaioli Alessandra, Giuliani Orietta, Vattiato Rosa, Zamagni Federica, Giorgi Rossi Paolo, Campari Cinzia, Canuti Debora, Di Felice Enza, Sassoli de Bianchi Priscilla, Ferretti Stefano, Bertozzi Nicoletta, Biggeri Annibale, Falcini Fabio, Di Felice Enza, Finarelli Alba Carola, Landi Patrizia, Naldoni Carlo, Sassoli de Bianchi Priscilla, Colamartini Americo, Borciani Elisabetta, Fornari Fabio, Gatti Giorgio, Pennini Francesca, Seghini Pietro, Dalla Fiora Cristian, Fattibene Claudio, Maradini Fabio, Michiara Maria, Orsi Paolo, Zurlini Corrado, Mangone Lucia, Paterlini Luisa, Sassatelli Romano, Carrozzi Giuliano, Corradini Rossella, Rossi Federica, Trande Paolo, Viani Simona, Bazzani Carmen, Bazzoli Franco, Cennamo Vincenzo, Giansante Chiara, Gualandi Giovanna, Manfredi Marilena, Mezzetti Francesca, Pasquini Adriana, Caprara Licia, De Lillo Margherita, Nannini Roberto, Carpanelli Maria Cristina, De Togni Aldo, Matarese Vincenzo, Palmonari Caterina, Pasquali Daniela, Zoli Giorgio, Dal Re Serena, Petrini Chiara, Serafini Monica, Vitali Benedetta, Gallinucci Mara, Imolesi Claudia, Palazzi Mauro, Ricci Enrico, Severi Mirna, Casale Coralba, Giovanardi Mauro, Trombetti Daniele,
Abstract
Abstract
Background
This study aimed to evaluate the effectiveness of a biennial faecal immunochemical test (FIT) screening programme in reducing annual colorectal cancer (CRC) incidence in its dynamic target population.
Methods
The target population included over 1,000,000 persons aged 50–69 living in a region of northern Italy. The average annual response rate to invitation was 51.4%. Each observed annual age-standardised (Europe) rate per 100,000 persons between 2005, the year of introduction of the programme, and 2016 was compared with each expected annual rate as estimated with age-period-cohort (men) and age-period (women) models.
Results
For both sexes, the rates observed in 1997–2004 and those expected in 2005–2016 were stable. Observed rates increased in 2005, peaked in 2006 (the first full year of screening), dropped significantly below the expected level in 2009, and continued to decrease until 2013 (the eighth full year), after which no further significant changes occurred. In the pooled years 2013–2016, the observed incidence rate per 100,000 persons was 102.2 [95% CI: 97.4, 107.1] for men, 75.6 [95% CI: 71.6, 79.7] for women and 88.4 [95% CI: 85.3, 91.5] for both sexes combined, with an observed:expected incidence rate ratio of 0.68 [95% CI: 0.65, 0.71], 0.79 [95% CI: 0.76, 0.82] and 0.72 [95% CI: 0.66, 0.81], respectively.
Discussion
The study provided multiple consistent proofs of a causal relationship between the introduction of screening and a stable 28% decrease in annual CRC incidence after eight years.
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology
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