The impact of the COVID-19 pandemic upon pancreatic cancer treatment (CONTACT Study): a UK national observational cohort study
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Published:2023-03-23
Issue:10
Volume:128
Page:1922-1932
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ISSN:0007-0920
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Container-title:British Journal of Cancer
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language:en
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Short-container-title:Br J Cancer
Author:
Hall Lewis A.ORCID, McKay Siobhan C., Halle-Smith James, Soane Joshua, Osei-Bordom Daniel-Clement, Goodburn Lesley, Magill Laura, Pinkney Thomas, Radhakrishna Ganesh, Valle Juan W.ORCID, Corrie PippaORCID, Roberts Keith J., Goodburn Lesley, Hughes Terry, Perry Rita, Walters Michael, Acharya Radhika, Binnersly Thomas, Brown Samuel J., Everitt Rebecca, Hargreaves Oscar, Hodgson Samuel, Parylo Jacek, Perrett Madeleine, Smith Daniel J., Thorne Thomas, Abouelazayem Mohamed, Bradley Alison, Currow Chelise, Fox Richard, Giles Benjamin, Kourdouli Amar, Mahmood Fahad, Moir John, Mowbray Nicholas, Shotton Rohan, Vivekananthan Cavitha, Zakeri Roxanna, Abbadi Reyad, Abbott Sian, Abdelrahim Hamza, Abukar Yusria, Adel Nader, Adwan Hussamuddin, Ahmed Marriam, Ahmed Shehzad, Ahmed Irfan, Akotat Ouiam, Al-Sarireh Bilal, Alamassi Amro, Aldous Gemma, Alkari Bassam, Almonib Ahmed, Amin Jasim, Anjum Muhammad Raheel, Aroori Somaiah, Arshad Ali, Arya Pallavi, Asfandyar Syed, Aslam Usama, Aspinall Richard, Athwal Tejinderjit, Azam Saima, Bailey Robert, Bandlamudi Nanda, Barker Sophie, Bashir Khalid, Bavikatte Akshay, Belchita Raluca, Beluso Ann, Bevan Katharine, Bhatti Imran, Boulbadaoui Amal, Boyce Tamsin, Bradley Neil, Brooks Corinne, Brown Christopher, Burns Stephanie, Butler Linda, Byrne Hannah, Canelo Ruben, Ceresa Carlo, Chadwick Georgina, Charlesworth Irene, Chase Thomas, Chen Patrick, Chhabra Raunaq, Chin Mei Ying, Choudhry Zeshan, Chung Yooyun, Ciocarlan Svetlana, Clark Jennifer, Clyde Danielle, Connolly Maureen, Connors Kathleen, Cormack Jonathan, Coyle Meghan, Crumley Andrew, Davies Nick, Davies Emma, de Liguori-Carino Nicola, Di Franco Filippo, Diong Kok, Doe Matt, Donovan Victoria, Downs Jennifer, Easton Trish, Ekong Tolu, Ekpenyong Utitofon, El-housseri Tarek, Elmaradny Ahmed, Elzubier Mohamed, Epanomeritakis Emmanouil, Erotocritou Marios, Ewing Iain, Fabelurin Christiana, Falk Stephen, Farrugia Alexia, Feretis Michael, Finch Guy, Findlay Alasdair, Fisher Simon, Fong Steven, Fox Katherine, Fung Xavier, Fusai Giuseppe, Gale Laura, Gall Tamara, Garcea Giuseppe, Gasem Jaber, Georgiades Fanourios, Geraghty Joe, Ghassemi Nader, Gherghab Mustafa, Giles Joanne, Gillmore Roopinder, Gilroy Leah, Goldsworthy Matthew, Grayston Alex, Green Jordan, Gurprashad Roy, Hajee-Adam Wafaa, Hajibandeh Shahin, Hallinan-Rhodes Clara, Hamed Adel, Hameed Waseem, Handa Siddartha, Hanna Michael, Hassan Mohammad, Havard Tim, Hayes Jennifer, Hayton Philip, Hebbar Madhu, Heenan Kerri-Marie, Higgins Christine, Ho Michael, Holroyd David, Howard Richard, Hughes Charlotte, Inayet Nashiz, Indayare Sahra, Ingmire Julie, Irving Glen, Ivimy Anita, Jackson Georgina, Jah Asif, Jamieson Nigel, Jaunoo Shameen, Javed Nasir, Jeevagan Arun, Jiao Long, Johnson Sarah, Jones Miriam, Jones Michael, Jones Claire, Jones Dylan, Jones Vicky, Jordan Caitlin, Jose Paul, Joshi Neerav, Joshi Kunal, Kane Daniel, Kapila Diya, Karim Syed, Kasimanickam Muthi, Kaur Mandeep, Kausar Ambareen, Keatley Ben, Kedzierski Adam, Kejariwal Deepak, Kelly Natasha, Khan Areeb, Khani Aria, Khokar Usman, Knibbs William, Kocher Hemant, Koumoutsos Ioannis, Kovammal Shemin, Kreppel Sarah, Kuganesan Tharsika, Kumar Yogesh, Kurien Reuben, Lal Nikhil, Lavelle Corina, Laverick Sophie, Laverty Lauren, Laxaman Hemant, Lee Alvin, Lloyd-Jones Karen, Lykoudis Pavlos, Mahalingam Aarini, Majkowska Agata, Majumdar Debasis, Malam Yogeshkumar, Mann Kulbir, Marsh Robyn, Martin Harry, Mcaleer Joseph, McCain Stephen, McCaughan Hannah, McCollum Catherine, McCormack Kieran, McDonald Claire, McGoran John, Mclellan Morag, Meilak Joseph, Menon Shyam, Menzies Donald, Milburn James, Millar Andrew, Minto Moeed, Mishra Amitabh, Mitha Zain, Mitra Vikramjit, Mogan Sathis, Mohamed Badreldin, Mohammadi-Zaniani Ghazaleh, Mohammed Yaser, Mohan Jaiganesh, Morris Samuel, Morrison Gary, Morrison Tamsin, Mortimer Matthew, Moulding Samuel, Mourad Moustafa, Mukherjee Sujit, Mustafa Ameer, Naik Keval, Naqvi Syed, Natarajan Deepika, Ngan Thomas, Noakes Tracey, Norris Tim, O’Connell Elizabeth, O’Kane Rebecca, O’Reilly David, O’Rourke William, Olabintan Olaolu, Ololade Samuel, Ong Seok Ling, Osunlusi Oluwafemi, Palejwala Altaf, Palepa Anna, Palmer Monica, Parisinos Constantinos, Parmar Chetan, Patel Panna, Pathak Samir, Pereira Stephen, Pericleous Stephanos, Phillips Rosemary, Pike Tom, Pillay Lushen, Pinheiro Joao, Pirjamali Parisa, Poolovadoo Yanish, Popa Mariuca, Powell-Brett Sarah, Prior-Ong Melissa, Propper David, Quinn Leonard, Radwan Khaled, Ralph Alyssa, Ramachandran Veena, Ramsamy Ganeshan, Rassam Hind, Ray-Chaudhuri Anjana, Reddy Srikanth, Reza Shahriar, Rezk Karim, Rice Paul, Richmond Lysia, Ripoll Brianda, Rizvi Syed, Robinson Sarah, Robson Natalie, Rogers Polly, Rowley Megan, Russell Thomas, Safarova Dana, Sagoo Harkiran, Samake Maurice, Sami Sharukh, Samraj Kumar, Sarmah Panchali, Saxton Edward, Scutt Bethany, Sellahewa Chaminda, Sen Gourab, Shaida Zara, Shandakumar Amrita, Sharer Nicholas, Shaukat Syed, Sheth Roosey, Shingler Guy, Shroll Amy, Siriwardena Ajith K., Skipworth James, Slater Sarah, Smith Conor, Smith Andrew, Sogaolu Opeyemi, Stevens Claire, Stewart Duncan, Stupalkowska Weronika, Sud Vikas, Sultan Zain, Summers Luke, Suresh Nikhil, Sutton Jonathan, Tan Wei Jian, Tan Chew, Tanase Andrei, Tanase Andrei, Tanno Lulu, Taylor Luke, Taylor Mark, Thakkar Rohan, Thomas Donna, Thompson Emily, Tinsley Benjamin, Toy Elizabeth, Tsang David, Tsirekidze Archil, Tsironis Dimitrios, Tucker Sophie, Turner Tracey, Udayachandran Varu, van Laarhoven Stijn, Vandadi Lakshmi Deepa, Varley Rebecca, Veeramootoo Darmarajah, Venkatachalapathy Suresh Vasan, Verma Ashwin, Vipond Mark, Waite Daniel, Ward Amy, Warner Ben, Waters Justin, West Alexander, Whitelaw Douglas, Williams Matthew, Williams Rhys, Wilson Phoebe, Yershov Danylo, Young Alistair, Zafar Muneeb, Zaman Osama, Zhao Melissa, , , , , ,
Abstract
Abstract
Introduction
CONTACT is a national multidisciplinary study assessing the impact of the COVID-19 pandemic upon diagnostic and treatment pathways among patients with pancreatic ductal adenocarcinoma (PDAC).
Methods
The treatment of consecutive patients with newly diagnosed PDAC from a pre-COVID-19 pandemic cohort (07/01/2019-03/03/2019) were compared to a cohort diagnosed during the first wave of the UK pandemic (‘COVID’ cohort, 16/03/2020-10/05/2020), with 12-month follow-up.
Results
Among 984 patients (pre-COVID: n = 483, COVID: n = 501), the COVID cohort was less likely to receive staging investigations other than CT scanning (29.5% vs. 37.2%, p = 0.010). Among patients treated with curative intent, there was a reduction in the proportion of patients recommended surgery (54.5% vs. 76.6%, p = 0.001) and increase in the proportion recommended upfront chemotherapy (45.5% vs. 23.4%, p = 0.002). Among patients on a non-curative pathway, fewer patients were recommended (47.4% vs. 57.3%, p = 0.004) or received palliative anti-cancer therapy (20.5% vs. 26.5%, p = 0.045). Ultimately, fewer patients in the COVID cohort underwent surgical resection (6.4% vs. 9.3%, p = 0.036), whilst more patients received no anti-cancer treatment (69.3% vs. 59.2% p = 0.009). Despite these differences, there was no difference in median overall survival between the COVID and pre-COVID cohorts, (3.5 (IQR 2.8–4.1) vs. 4.4 (IQR 3.6–5.2) months, p = 0.093).
Conclusion
Pathways for patients with PDAC were significantly disrupted during the first wave of the COVID-19 pandemic, with fewer patients receiving standard treatments. However, no significant impact on survival was discerned.
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology
Reference34 articles.
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