Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis-Reference-Cited by-同舟云学术

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Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis

Published:2018-10 Issue:8 Volume:119 Page:928-936
ISSN:0007-0920
Container-title:British Journal of Cancer
language:en
Short-container-title:Br J Cancer

Author:

Gerber David E.,Beg M. Shaalan,Fattah Farjana,Frankel Arthur E.,Fatunde Oluwatomilade,Arriaga Yull,Dowell Jonathan E.,Bisen Ajit,Leff Richard D.,Meek Claudia C.,Putnam William C.,Kallem Raja Reddy,Subramaniyan Indhumathy,Dong Ying,Bolluyt Joyce,Sarode Venetia,Luo Xin,Xie Yang,Schwartz Brian,Boothman David A.

Funder

U.S. Department of Health & Human Services | NIH | National Cancer Institute

Cancer Prevention and Research Institute of Texas

ArQuol Inc

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Link

http://www.nature.com/articles/s41416-018-0278-4.pdf

Reference43 articles.

1. Pink, J. J. et al. NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity. J. Biol. Chem. 275, 5416–5424 (2000).

2. Bentle, M. S., Bey, E. A., Dong, Y., Reinicke, K. E. & Boothman, D. A. New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors. J. Mol. Histol. 37, 203–218 (2006).

3. Marin, A. et al. DT-diaphorase and cytochrome B5 reductase in human lung and breast tumours. Br. J. Cancer 76, 923–929 (1997).

4. Belinsky, M. & Jaiswal, A. K. NAD(P)H:quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues. Cancer Metastasis Rev. 12, 103–117 (1993).

5. Ough, M. et al. Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1. Cancer Biol. Ther. 4, 95–102 (2005).

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