Long-term risk of subsequent cancer incidence among hereditary and nonhereditary retinoblastoma survivors
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Published:2021-01-21
Issue:7
Volume:124
Page:1312-1319
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ISSN:0007-0920
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Container-title:British Journal of Cancer
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language:en
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Short-container-title:Br J Cancer
Author:
Schonfeld Sara J.ORCID, Kleinerman Ruth A.ORCID, Abramson David H., Seddon Johanna M., Tucker Margaret A.ORCID, Morton Lindsay M.
Abstract
Abstract
Background
Increased sarcoma and melanoma risks after hereditary retinoblastoma are well established, whereas less is known about epithelial subsequent malignant neoplasms (SMNs) and risks for multiple (≥2) SMNs.
Methods
Leveraging long-term follow-up and detailed histologic information, we quantified incident SMN risk among 1128 hereditary and 924 nonhereditary retinoblastoma survivors (diagnosed 1914–2006; follow-up through 2016). Standardised incidence ratios (SIRs) compared cancer risk after retinoblastoma relative to the general population. We estimated cumulative incidence accounting for competing risk of death.
Results
Hereditary survivors had statistically significantly increased SMN risk (N = 239; SIR = 11.9; 95% confidence interval [CI] 10.4–13.5), with SIRs >80-fold for sarcomas, nasal cavity tumours and pineoblastoma. Significantly increased risks were also observed for melanoma and central nervous system, oral cavity and breast SMNs (SIRs = 3.1–17), but not the uterus, kidney, lung, bladder, pancreas or other types. Cumulative incidence 50 years following hereditary retinoblastoma was 33.1% (95% CI 29.0–37.2) for a first SMN and 6.0% (95% CI 3.8–8.2) for a second SMN. SMN risk was not increased after nonhereditary retinoblastoma (N = 25; SIR = 0.8; 95% CI 0.5–1.2).
Conclusion
Beyond the established sarcoma and melanoma risks after hereditary retinoblastoma, we demonstrate increased risk for a more limited number of epithelial malignancies than previously suggested. Cumulative incidence estimates emphasise long-term SMN burden after hereditary retinoblastoma.
Funder
Intramural Program, National Cancer Institute, National Institutes of Health.
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology
Reference26 articles.
1. Marees, T., Moll, A. C., Imhof, S. M., de Boer, M. R., Ringens, P. J. & van Leeuwen, F. E. Risk of second malignancies in survivors of retinoblastoma: more than 40 years of follow-up. J. Natl Cancer Inst. 100, 1771–1779 (2008). 2. MacCarthy, A., Bayne, A. M., Brownbill, P. A., Bunch, K. J., Diggens, N. L., Draper, G. J. et al. Second and subsequent tumours among 1927 retinoblastoma patients diagnosed in Britain 1951-2004. Br. J. Cancer 108, 2455–2463 (2013). 3. Wong, J. R., Morton, L. M., Tucker, M. A., Abramson, D. H., Seddon, J. M., Sampson, J. N. et al. Risk of subsequent malignant neoplasms in long-term hereditary retinoblastoma survivors after chemotherapy and radiotherapy. J. Clin. Oncol. 32, 3284–3290 (2014). 4. Temming, P., Arendt, M., Viehmann, A., Eisele, L., Le Guin, C. H., Schundeln, M. M. et al. Incidence of second cancers after radiotherapy and systemic chemotherapy in heritable retinoblastoma survivors: a report from the German reference center. Pediatr. Blood Cancer 64, 71–80 (2017). 5. Kleinerman, R. A., Tucker, M. A., Tarone, R. E., Abramson, D. H., Seddon, J. M., Stovall, M. et al. Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: an extended follow-up. J. Clin. Oncol. 23, 2272–2279 (2005).
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