Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/35084141.pdf
Reference17 articles.
1. Gusella, J. F. & Macdonald, M. E. Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease. Nature Rev. Neurosci. 1, 109– 115 (2000).
2. Perutz, M. F., Johnston, T., Suzuki, M. & Finch, J. T. Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases. Proc. Natl Acad. Sci. USA 91, 5355– 5358 (1994).
3. Davies, S. W. et al. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90, 537– 548 (1997).
4. DiFiglia, M. et al. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990– 1993 (1993).
5. Clarke, G. et al. A one-hit model of cell death in inherited neuronal degenerations. Nature 406, 195– 199 (2000).
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