Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Chemical Engineering,General Chemistry
Link
http://www.nature.com/articles/nchem.2578.pdf
Reference28 articles.
1. Truppo, M. D., Rozzell, J. D. & Turner, N. J. Efficient production of enantiomerically pure chiral amines at concentrations of 50 g/L using transaminases. Org. Process Res. Dev. 14, 234–237 (2010).
2. Savile, C. K. et al. Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture. Science 329, 305–309 (2010).
3. Fuchs, M., Farnberger, J. E. & Kroutil, W. The industrial age of biocatalytic transamination. Eur. J. Org. Chem. 2015, 6965–6982 (2015).
4. Steffen-Munsberg, F. et al. Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications. Biotechnol. Adv. 33, 566–604 (2015).
5. Koszelewski, D., Tauber, K., Faber, K. & Kroutil, W. ω-Transaminases for the synthesis of non-racemic α-chiral primary amines. Trends Biotechnol. 28, 324–332 (2010).
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