STAT3 can serve as a hit in the process of malignant transformation of primary cells
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/cdd201220.pdf
Reference38 articles.
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2. Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci USA 2007; 104: 7391–7396.
3. Schindler C, Levy DE, Decker T . JAK-STAT signaling: from interferons to cytokines. J Biol Chem 2007; 282: 20059–20063.
4. Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J et al. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 1995; 269: 81–83.
5. Bromberg JF, Horvath CM, Besser D, Lathem WW, Darnell Jr JE . Stat3 activation is required for cellular transformation by v-src. Mol Cell Biol 1998; 18: 2553–2558.
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