Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy-Reference-Cited by-同舟云学术

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Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy

Published:2008-03-13 Issue:4 Volume:22 Page:708-722
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

McCubrey J A,Steelman L S,Abrams S L,Bertrand F E,Ludwig D E,Bäsecke J,Libra M,Stivala F,Milella M,Tafuri A,Lunghi P,Bonati A,Martelli A M

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/leu200827.pdf

Reference180 articles.

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2. Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ et al. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 1994; 370: 527–532.

3. Vey N, Mozzinconacci MJ, Groulet-Martinec A, Debono S, Finetti P, Carbuccia N et al. Identification of new classes among acute myelogenous leukaemias with normal karyotype using gene expression profiling. Oncogene 2004; 23: 9381–9391.

4. Kiyoi H, Towatari M, Yokota S, Hamaguchi M, Ohno R, Saito H et al. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia 1998; 12: 1333–1337.

5. Shimada A, Taki T, Tabuchi K, Tawa A, Horibe K, Tsuchida M et al. KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group. Blood 2006; 107: 1806–1809.

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