Generation of incednine derivatives by mutasynthesis
Author:
Funder
MEXT | Japan Society for the Promotion of Science
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology
Link
http://www.nature.com/articles/s41429-020-0329-y.pdf
Reference18 articles.
1. Futamura Y, Sawa R, Umezawa Y, et al. Discovery of incednine as a potent modulator of the anti-apoptotic function of Bcl-xL from microbial origin. J Am Chem Soc. 2008;130:1822–3.
2. Lim YH, Wong FT, Yeo WL, et al. Auroramycin: a potent antibiotic from Streptomyces roseosporus by CRISPR-Cas9 activation. ChemBioChem. 2018;19:1716–9.
3. Schulz D, Nachtigall J, Geisen U, et al. Silvalactam, a 24-membered macrolactam antibiotic produced by Streptomyces sp. Tü 6392. J Antibiot. 2012;65:369–72.
4. Takaishi M, Kudo F, Eguchi T. Biosynthetic pathway of 24-membered macrolactam glycoside incednine. Tetrahedron. 2008;64:6651–6.
5. Takaishi M, Kudo F, Eguchi T. A unique pathway for the 3-aminobutyrate starter unit from L-glutamate through β-glutamate during biosynthesis of the 24-membered macrolactam antibiotic, incednine. Org Lett. 2012;14:4591–3.
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2. Biosynthesis of β-Amino Acid-Containing Macrolactam Polyketides;New Tide of Natural Product Chemistry;2023
3. Mutasynthesis of Medicinally Significant Natural Products Through Manipulation of Gene Governing Starter Unit;Current Organic Chemistry;2021-09-02
4. Mutational Biosynthesis of Hitachimycin Analogs Controlled by the β-Amino Acid–Selective Adenylation Enzyme HitB;ACS Chemical Biology;2021-02-24
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