Author:
Morel Chantal M.,Lindahl Olof,Harbarth Stephan,de Kraker Marlieke E. A.,Edwards Suzanne,Hollis Aidan
Abstract
AbstractThe scarcity of novel antibiotic compounds in a time of increasing resistance rates has begun to ring alarm bells at the highest echelons of government. Large new financial incentives to accelerate antibiotic research and development, such as market entry rewards (MERs), are being considered. However, there is little focus on how to sustain the efficacy of new, promising antibiotics reaching the market. Currently, inappropriate use of antibiotics is commonplace, which has accelerated resistance development. In an attempt to halt this trend, antibiotic stewardship policies are being implemented in many resource-rich settings. Unfortunately, this has not yet had an impact on the amount of antibiotics being prescribed globally. One important hurdle is misalignment of incentives. While governments and health services are incentivized to promote prudent use of this common good, pharmaceutical companies are incentivized to increase volume of sales to maximize profits. This problem must be addressed or else the major efforts going into developing new antibiotics will be in vain. In this paper we outline an approach to realign the incentives of pharmaceutical companies with wider antibiotic conservation efforts by making a staged bonus a component of an MER for antibiotic developers when resistance to their drug remains low over time. This bonus could address the lack of stewardship focus in any innovation-geared incentive.
Funder
Swiss National Fund
Vetenskapsrådet
Canadian Institute for Health Research
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology
Reference34 articles.
1. World Bank. Drug resistant infections: a threat to our economic future (vol. 2): final report. 2017. Report Number 114679. http://documents.worldbank.org/curated/en/323311493396993758/pdf/114679-REVISED-v2-Drug-Resistant-Infections-Final-Report.pdf.
2. UK Review on Antimicrobial Resistance. (chaired by Jim O’Neill). Tackling drug-resistant infections globally: final report and recommendations. 2016. https://amr-review.org/Publications.html.
3. Simpkin VL, Renwick MJ, Kelly R, Mossialos E. Incentivising innovation in antibiotic drug discovery and development: progress, challenges and next steps. J Antibiot. 2017;70:1087. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746591/#__ffn_sectitle.
4. Mossialos E, Morel CM, Edwards SE, Berensen J, Gemmill-Toyama M, Brogen D. Policies and incentives for promoting innovation in antibiotic research. European Observatory on Health Systems and Policies. 2010. http://www.euro.who.int/__data/assets/pdf_file/0011/120143/E94241.pdf.
5. Morel CM, Mossialos E. Stoking the antibiotic pipeline. BMJ. 2010;340:1115–8. http://www.bmj.com/bmj/section-pdf/186569?path=/bmj/340/7756/Analysis.full.pdf.
Cited by
63 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献