Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06
Author:
Funder
Natural Science Foundation of Zhejiang Province
Natural Science Foundation of Huzhou City
Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41429-024-00754-y.pdf
Reference10 articles.
1. Zhang J, et al. Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase. Microb Cell Fact. 2015;14:152–63.
2. Huang J, et al. Gene replacement for the generation of designed novel avermectin derivatives with enhanced acaricidal and nematicidal activities. Appl Environ Microbiol. 2015;81:5326–34.
3. Wan X, et al. New tenvermectin analogs obtained by microbial conversion with Saccharopolyspora erythraea. J Antibiot. 2017;70:190–2.
4. Zhang H, et al. Acyltransferase domain swapping for the production of tenvermectin B metabolites in genetically engineered strain Streptomyces avermitilis HU02. J Agric Food Chem. 2022;70:11994–2003.
5. Wang JD, et al. HS071, a new furan-type cytotoxic metabolite from Streptomyces sp. HS-HY-071. J Antibiot. 2008;61:623–26.
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