Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing-Reference-Cited by-同舟云学术

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Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing

Published:2016-03-31 Issue:1 Volume:6 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Miyaoka Yuichiro,Berman Jennifer R.,Cooper Samantha B.,Mayerl Steven J.,Chan Amanda H.,Zhang Bin,Karlin-Neumann George A.,Conklin Bruce R.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep23549.pdf

Reference38 articles.

1. Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816–821 (2012).

2. Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823–826 (2013).

3. Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819–823 (2013).

4. Ran, F. A. et al. Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity. Cell 154, 1380–1389 (2013).

5. Mali, P. et al. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol 31, 833–838 (2013).

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