Rational Design of Therapeutic siRNAs: Minimizing Off-targeting Potential to Improve the Safety of RNAi Therapy for Huntington's Disease
Author:
Publisher
Elsevier BV
Subject
Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine
Reference41 articles.
1. Ribonuclease activity and RNA binding of recombinant human Dicer;Provost;EMBO J,2002
2. The widespread regulation of microRNA biogenesis, function and decay;Krol;Nat Rev Genet,2010
3. The nuclear RNase III Drosha initiates microRNA processing;Lee;Nature,2003
4. The Microprocessor complex mediates the genesis of microRNAs;Gregory;Nature,2004
5. Asymmetry in the assembly of the RNAi enzyme complex;Schwarz;Cell,2003
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