Embryonic stem cells in drug discovery
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd1281.pdf
Reference118 articles.
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2. Abuin, A., Holt, K. H., Platt, K. A., Sands, A. T. & Zambrowicz, B. P. Full-speed mammalian genetics; in vivo target validation in the drug discovery process. Trends Biotechnol. 20, 261–268 (2002). References 1 and 2 are excellent reviews on the application of genetically modified mice in drug discovery.
3. Crawley, J. N. Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities and specific behavioral tests. Brain Res. 835, 18–26 (1999).
4. van der Staay, F. J. & Steckler, T. Behavioral phenotyping of mouse mutants. Behav. Brain Res. 125, 3–12 (2001).
5. Doevendans, P. A., Daemen, M. J., de Muinck, E. D. & Smits, J. F. Cardiovascular phenotyping in mice. Cardiovasc. Res. 39, 34–49 (1998).
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