Transgenic analysis of thymocyte signal transduction
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri703.pdf
Reference85 articles.
1. Crompton, T., Gilmour, K. C. & Owen, M. J. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte. Cell 86, 243–251 (1996).
2. Pallard, C. et al. Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors. Immunity 10, 525–535 (1999).
3. Perlmutter, R. M. & Alberola-Ila, J. The use of dominant-negative mutations to elucidate signal transduction pathways in lymphocytes. Curr. Opin. Immunol. 8, 285–290 (1996).
4. Rincon, M. MAP-kinase signaling pathways in T cells. Curr. Opin. Immunol. 13, 339–345 (2001).Two excellent reviews: reference 3 covers most of the key experiments using transgenesis to look at the function of SRC kinases and Ras GTPases in the thymus; reference 4 is a comprehensive analysis of how MAP kinases control lymphocyte biology.
5. Allen, J. M., Forbush, K. A. & Perlmutter, R. M. Functional dissection of the Lck proximal promoter. Mol. Cell. Biol. 12, 2758–2768 (1992).
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