A point mutation in the extracellular domain of KIT promotes tumorigenesis of mastcells via ligand-independent auto-dimerization
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep09775.pdf
Reference52 articles.
1. Broxmeyer, H. E. et al. The kit receptor and its ligand, steel factor, as regulators of hemopoiesis. Cancer Cells 3, 480–487 (1991).
2. Halaban, R. Growth factors and tyrosine protein kinases in normal and malignant melanocytes. Cancer Metastasis Rev. 10, 129–140 (1991).
3. Huizinga, J. D. et al. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 373, 347–349 (1995).
4. Blume-Jensen, P. et al. Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis. EMBO J. 10, 4121–4128 (1991).
5. Tsai, M., Chen, R., Tam, S., Blenis, J. & Galli, S. J. Activation of MAP kinases, pp90rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or FcRI: rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells. Eur. J. Immunol. 23, 3286–3291 (1993).
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