Therapeutic targeting of the PDGF and TGF-β-signaling pathways in hepatic stellate cells by PTK787/ZK22258

Author:

Liu Yuqing,Wen Xiao Ming,Lui Eric Lik Hang,Friedman Scott L,Cui Wei,Ho Nancy Pei Shan,Li Lei,Ye Tao,Fan Sheung Tat,Zhang Hui

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology,Pathology and Forensic Medicine

Reference50 articles.

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2. Geerts A, Lazou JM, De Bleser P, et al Tissue distribution, quantitation and proliferation kinetics of fat-storing cells in carbon tetrachloride-injured rat liver. Hepatology 1991;13:1193–1202.

3. Friedman SL . Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000;275:2247–2250.

4. Pinzani M, Milani S, Grappone C, et al Expression of platelet-derived growth factor in a model of acute liver injury. Hepatology 1994;19:701–707.

5. Pinzani M, Milani S, Herbst H, et al Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis. Am J Pathol 1996;148:785–800.

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