Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model

Author:

Xin Xiping,Majumder Mousumi,Girish Gannareddy V,Mohindra Vik,Maruyama Takayuki,Lala Peeyush K

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology,Pathology and Forensic Medicine

Reference54 articles.

1. Williams CS, Mann M, DuBois RN . The role of cyclooxygenases in inflammation, cancer, and development. Oncogene 1999;18:7908–7916.

2. Wang MT, Honn KV, Nie D . Cyclooxygenases, prostanoids, and tumor progression. Cancer Metastasis Rev 2007;26:525–534.

3. Harris RE . . Humana Press: Totowa, NJ, 2003.

4. Liu CH, Chang SH, Narko K, et al. Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. J Biol Chem 2001;276:18563–18569.

5. Howe LR, Subbaramaiah K, Patel J, et al. Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer. Cancer Res 2002;62:5405–54057.

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