Residual dormant cancer stem-cell foci are responsible for tumor relapse after antiangiogenic metronomic therapy in hepatocellular carcinoma xenografts

Author:

Martin-Padura Ines,Marighetti Paola,Agliano Alice,Colombo Federico,Larzabal Leyre,Redrado Miriam,Bleau Anne-Marie,Prior Celia,Bertolini Francesco,Calvo Alfonso

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology,Pathology and Forensic Medicine

Reference45 articles.

1. Llovet JM, Burroughs A, Bruix J . Hepatocellular carcinoma. Lancet 2003;362:1907–1917.

2. Voiculescu M, Winkler RE, Moscovici M, et al. Chemotherapies and targeted therapies in advanced hepatocellular carcinoma: from laboratory to clinic. J Gastrointestin Liver Dis 2008;17:315–322.

3. Hoshida Y, Villanueva A, Kobayashi M, et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med 2008;359:1995–2004.

4. Hanahan D, Bergers G, Bergsland E . Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J Clin Invest 2000;105:1045–1047.

5. Bertolini F, Paul S, Mancuso P, et al. Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells. Cancer Res 2003;63:4342–4346.

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