Impact of CYP2C8*3 on paclitaxel clearance: a population pharmacokinetic and pharmacogenomic study in 93 patients with ovarian cancer

Author:

Bergmann T K,Brasch-Andersen C,Gréen H,Mirza M,Pedersen R S,Nielsen F,Skougaard K,Wihl J,Keldsen N,Damkier P,Friberg L E,Peterson C,Vach W,Karlsson M O,Brosen K

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,Genetics,Molecular Medicine

Reference50 articles.

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3. Harris JW, Rahman A, Kim BR, Guengerich FP, Collins JM . Metabolism of taxol by human hepatic microsomes and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme. Cancer Res 1994; 54: 4026–4035.

4. Rahman A, Korzekwa KR, Grogan J, Gonzalez FJ, Harris JW . Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8. Cancer Res 1994; 54: 5543–5546.

5. Kumar G, Ray S, Walle T, Huang Y, Willingham M, Self S et al. Comparative in vitro cytotoxic effects of taxol and its major human metabolite 6 alpha-hydroxytaxol. Cancer Chemother Pharmacol 1995; 36: 129–135.

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