The temporal relationship between ABCB1 promoter hypomethylation, ABCB1 expression and acquisition of drug resistance
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology,Genetics,Molecular Medicine
Link
http://www.nature.com/articles/tpj20101.pdf
Reference49 articles.
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3. Gottesman MM, Ambudkar SV . Overview: ABC transporters and human disease. J Bioenerg Biomembr 2001; 33: 453–458.
4. Kantharidis P, El-Osta A, deSilva M, Wall DM, Hu XF, Slater A et al. Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance. Clin Cancer Res 1997; 3: 2025–2032.
5. Desiderato L, Davey MW, Piper AA . Demethylation of the human MDR1 5′ region accompanies activation of P-glycoprotein expression in a HL60 multidrug resistant subline. Somat Cell Mol Genet 1997; 23: 391–400.
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