PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology
Link
http://www.nature.com/articles/ncb1346.pdf
Reference32 articles.
1. Arias, E. E. & Walter, J. C. Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. Genes Dev. 19, 114–126 (2005).
2. Li, A. & Blow, J. J. Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus. EMBO J. 24, 395–404 (2005).
3. Maiorano, D., Krasinska, L., Lutzmann, M. & Mechali, M. Recombinant Cdt1 induces rereplication of G2 nuclei in Xenopus egg extracts. Curr. Biol. 15, 146–153 (2005).
4. Thomer, M., May, N. R., Aggarwal, B. D., Kwok, G. & Calvi, B. R. Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2. Development 131, 4807–4818 (2004).
5. Yoshida, K., Takisawa, H. & Kubota, Y. Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs. Genes Cells 10, 63–73 (2005).
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