Pervasive chromosomal instability and karyotype order in tumour evolution
Author:
Watkins Thomas B. K., Lim Emilia L., Petkovic MarinaORCID, Elizalde SergiORCID, Birkbak Nicolai J.ORCID, Wilson Gareth A., Moore David A., Grönroos EvaORCID, Rowan Andrew, Dewhurst Sally M., Demeulemeester JonasORCID, Dentro Stefan C., Horswell StuartORCID, Au Lewis, Haase KerstinORCID, Escudero MickaelORCID, Rosenthal Rachel, Bakir Maise Al, Xu Hang, Litchfield Kevin, Lu Wei TingORCID, Mourikis Thanos P., Dietzen Michelle, Spain Lavinia, Cresswell George D.ORCID, Biswas DhruvaORCID, Lamy Philippe, Nordentoft Iver, Harbst KatjaORCID, Castro-Giner FrancescORCID, Yates Lucy R., Caramia FrancoORCID, Jaulin FannyORCID, Vicier Cécile, Tomlinson Ian P. M., Brastianos Priscilla K., Cho Raymond J.ORCID, Bastian Boris C.ORCID, Dyrskjøt LarsORCID, Jönsson Göran B., Savas PeterORCID, Loi ShereneORCID, Campbell Peter J.ORCID, Andre FabriceORCID, Luscombe Nicholas M.ORCID, Steeghs Neeltje, Tjan-Heijnen Vivianne C. G., Szallasi Zoltan, Turajlic SamraORCID, Jamal-Hanjani Mariam, Van Loo PeterORCID, Bakhoum Samuel F., Schwarz Roland F.ORCID, McGranahan NicholasORCID, Swanton CharlesORCID
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Reference56 articles.
1. Zack, T. I. et al. Pan-cancer patterns of somatic copy number alteration. Nat. Genet. 45, 1134–1140 (2013). 2. Bolhaqueiro, A. C. F. et al. Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids. Nat. Genet. 51, 824–834 (2019). 3. Davoli, T. et al. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell 155, 948–962 (2013). 4. Turajlic, S. et al. Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal. Cell 173, 595–610 (2018). 5. McGranahan, N. et al. Cancer chromosomal instability: therapeutic and diagnostic challenges. ‘Exploring aneuploidy: the significance of chromosomal imbalance’ review series. EMBO Rep. 13, 528–538 (2012).
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