Insufficient evidence for non-neutrality of synonymous mutations-Reference-Cited by-同舟云学术

Insufficient evidence for non-neutrality of synonymous mutations

Published:2023-04-19 Issue:7957 Volume:616 Page:E8-E9
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Kruglyak Leonid^ORCID,Beyer Andreas^ORCID,Bloom Joshua S.^ORCID,Grossbach Jan^ORCID,Lieberman Tami D.,Mancuso Christopher P.,Rich Matthew S.,Sherlock Gavin^ORCID,Kaplan Craig D.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

https://www.nature.com/articles/s41586-023-05865-4.pdf

Reference12 articles.

1. Dhindsa, R. S. et al. A minimal role for synonymous variation in human disease. Am. J. Hum. Genet. 109, 2105–2109 (2022).

2. Presnyak, V. et al. Codon optimality is a major determinant of mRNA stability. Cell 160, 1111–1124 (2015).

3. Hanson, G. & Coller, J. Codon optimality, bias and usage in translation and mRNA decay. Nat. Rev. Mol. Cell Biol. 19, 20–30 (2018).

4. Bae, H. & Coller, J. Codon optimality-mediated mRNA degradation: linking translational elongation to mRNA stability. Mol. Cell 82, 1467–1476 (2022).

5. Shen, X., Song, S., Li, C. & Zhang, J. Synonymous mutations in representative yeast genes are mostly strongly non-neutral. Nature 606, 725–731 (2022).

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