CRISPR screen in regulatory T cells reveals modulators of Foxp3-Reference-Cited by-同舟云学术

CRISPR screen in regulatory T cells reveals modulators of Foxp3

Published:2020-04-29 Issue:7812 Volume:582 Page:416-420
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Cortez Jessica T.^ORCID,Montauti Elena,Shifrut Eric,Gatchalian Jovylyn,Zhang Yusi,Shaked Oren,Xu Yuanming,Roth Theodore L.,Simeonov Dimitre R.^ORCID,Zhang Yana,Chen Siqi^ORCID,Li Zhongmei,Woo Jonathan M.,Ho Josephine,Vogel Ian A.,Prator Grace Y.,Zhang Bin,Lee Youjin,Sun Zhaolin,Ifergan Igal,Van Gool Frédéric,Hargreaves Diana C.,Bluestone Jeffrey A.^ORCID,Marson Alexander^ORCID,Fang Deyu

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41586-020-2246-4.pdf

Reference59 articles.

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2. Zhou, X. et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat. Immunol. 10, 1000–1007 (2009).

3. Bailey-Bucktrout, S. L. & Bluestone, J. A. Regulatory T cells: stability revisited. Trends Immunol. 32, 301–306 (2011).

4. Overacre-Delgoffe, A. E. & Vignali, D. A. A. Treg fragility: a prerequisite for effective antitumor immunity? Cancer Immunol. Res. 6, 882–887 (2018).

5. Bluestone, J. A. & Tang, Q. Treg cells-the next frontier of cell therapy. Science 362, 154–155 (2018).

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