Smoothened stimulation by membrane sterols drives Hedgehog pathway activity-Reference-Cited by-同舟云学术

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity

Published:2019-07 Issue:7764 Volume:571 Page:284-288
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Deshpande Ishan,Liang Jiahao,Hedeen Danielle,Roberts Kelsey J.,Zhang Yunxiao,Ha Betty,Latorraca Naomi R.,Faust Bryan,Dror Ron O.,Beachy Philip A.,Myers Benjamin R.,Manglik Aashish

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41586-019-1355-4.pdf

Reference58 articles.

1. Briscoe, J. & Thérond, P. P. The mechanisms of Hedgehog signalling and its roles in development and disease. Nat. Rev. Mol. Cell Biol. 14, 416–429 (2013).

2. Wu, F., Zhang, Y., Sun, B., McMahon, A. P. & Wang, Y. Hedgehog signaling: from basic biology to cancer therapy. Cell Chem. Biol. 24, 252–280 (2017).

3. Huang, P. et al. Cellular cholesterol directly activates Smoothened in Hedgehog signaling. Cell 166, 1176–1187.e1114 (2016).

4. Huang, P. et al. Structural basis of Smoothened activation in Hedgehog signaling. Cell 174, 312–324.e316 (2018).

5. Byrne, E. F., Luchetti, G., Rohatgi, R. & Siebold, C. Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates. Curr. Opin. Cell Biol. 51, 81–88 (2018).

Cited by 163 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The path to the G protein‐coupled receptor structural landscape: Major milestones and future directions;British Journal of Pharmacology;2024-08-29

2. GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade;PLOS Biology;2024-08-13

3. Liver Extracellular Vesicles and Particles Enriched β-Sitosterol Effectively Promote Liver Regeneration in Mice;International Journal of Nanomedicine;2024-08

4. A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened;Cell Chemical Biology;2024-07

5. Genetically predicted TWEAK mediates the association between lipidome and Keratinocyte Carcinomas;Skin Research and Technology;2024-06-26